Dr. Aiten Farzalieva
Ivanovo Research Institute of Maternity and Childhood, Russian FederationTitle: CD163-positive alternatively activated monocytes as a marker of early miscarriage
Abstract
The early threat of abortion does not lose its relevance among the most significant problems of modern obstetrics. The impairment of immune mechanisms is considered one of the most significant pathogenetic factors.
The Aim: To develop a new method for predicting spontaneous miscarriage in women with threatened miscarriage at early stages of gestation, based on determining the content of alternatively activated monocytes expressing the CD163 scavenger receptor in peripheral venous blood.
Material and methods: 71 women were examined in the period of 5-12 weeks of pregnancy, pregnancy ended in timely delivery in 54 women (Group 1), spontaneous miscarriage (in early and late pregnancy) in 17 women (Group 2). The relative content of CD14+CD16++ monocytes bearing the CD163 scavenger receptor was determined on a FACScanto II flow cytometer (Becton Dickinson, USA).
Results: In women of the examined groups, the content of classically and intermediately activated monocytes expressing the scavenger receptor CD163 did not have a statistically significant difference. However, the content of alternatively activated monocytes expressing the CD163 scavenger receptor in women whose pregnancy ended in spontaneous miscarriage was statistically different from those in women whose pregnancy ended in timely delivery.
Conclusions: The content of alternatively activated monocytes expressing the CD163 scavenger receptor in peripheral blood can be used as a predictor of spontaneous miscarriage in women with threatened early miscarriage.
Biography
Farzalieva Aiten Vidadiyevna graduated with honors from a secondary school in 2009. She studied at the Ivanovo City Medical Academy from 2009 to 2015 and studied in residency in obstetrics and gynecology at the Scientific Research Institute of Motherhood and Childhood named after V.N. Gorodkov in the city of Ivanovo from 2015 to 2017 and also, she was a postgraduate student in obstetrics and gynecology at the Research Institute of Motherhood and Childhood named after V.N. Gorodkov from 2017 to 2022. She currently defended her Ph.D.
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